Endolysosomal
Ion Channel Lab
Munich
Key publications
Xu M, Zhong XZ, Huang P, Jaślan D, Wang P, Sun X, Weiden EM, El Hiani Y, Grimm C*, Dong XP*. TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P. PNAS 2023 Aug 22;120(34):e2215777120. doi: 10.1073/pnas.2215777120.
Martucci LL, Launay JM, Kawakami N, Sicard C, Desvignes N, Dakouane-Giudicelli M, Spix B, Têtu M, Gilmaire F-O, Paulcan S, Callebert J, Vaillend C, Bracher F, Grimm C, Fossier P, de la Porte S, Sakamoto S, Morris J, Galione A, Granon S, Cancela J-M: Endo-lysosomal two-pore channels regulate social behaviour by controlling oxytocin and vasopressin secretion. PNAS 2023 120(7):e2213682120. doi: 10.1073/pnas.2213682120.
- Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Do AND, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M: CLN3 is required for the efflux of glycerophosphodiesters from lysosomes. Nature 2022 Sep 21. doi: 10.1038/s41586-022-05221-y.
- Scotto Rosato A*, Krogsaeter E*, Jaślan D, Abrahamian C, Montefusco S, Soldati C, Spix B, Böck J, Pizzo, MT, Grieco, G., Wyatt A, Wünkhaus D, Passon M, Stieglitz M, Keller M, Hermey G, Markmann S, Gruber-Schoffnegger D, Cotman S, Johannes L, Crusius D, Boehm U, Wahl-Schott C, Biel M, Bracher F, De Leonibus, E, Polishchuk E, Medina DL, Paquet D, Grimm C#: TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1 and Batten disease. EMBO Mol Med 2022.Sep 7;14(9):e15377. doi: 10.15252/emmm.202115377.
- Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE, Abrahamian C, Keller M, Hartmann J, Scotto Rosato A, Weiden E-M, Bracher F, Yule DI, Grimm C#, Patel, S: Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes. Nature Commun 2022 Jan 14;13(1):318. doi: 10.1038/s41467-021-27860-x.
- Spix B, Butz ES, Chen C-C, Scotto Rosato A, Tang R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, Briukhovetska D, Ansari M, Günes Günsel G, Conlon TM, Wyatt A, Wetzel S, Teupser D, Holdt LM, Ectors F, Boekhoff I, Boehm U, García-Añoveros J, Saftig P, Giera M, Kobold S, Schiller HB, Zierler S, Gudermann T, Wahl-Schott C, Bracher F, Yildirim AÖ, Biel M, Grimm C#: Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nature Commun 2022 Jan 13(1):318. doi: 10.1038/s41467-021-27860-x.
- Soldati C, Lopez-Fabuel I, Wanderlingh LG, Garcia-Macia M, Monfregola J, Esposito A, Napolitano G, Guevara-Ferrer M, Scotto Rosato A, Krogsaeter EK, Paquet D, Grimm C, Montefusco S, Braulke T, Storch S, Mole SE, De Matteis MA, Ballabio A, Sampaio JL, McKay T, Johannes L, Bolaños JP, Medina DL. Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype. EMBO Mol Med 2021 Aug 19:e13742. doi: 10.15252/emmm.202013742. Online ahead of print.
- Chen C-C, Krogsaeter E, Butz E, Li Y, Puertollano R, Wahl-Schott C, Biel M, Grimm C#: TRPML2 is an osmo-/mechano-sensitive cation channel in endolysosomal organelles. Science Adv, 6(46):eabb5064, 2020.
- Arlt E, Fraticelli M, Tsvilovskyy V, Nadolni W, Breit A, O'Neill TJ, Resenberger S, Wennemuth G, Wahl-Schott C, Biel M, Grimm C, Freichel M, Gudermann T, Klugbauer N, Boekhoff I, Zierler S. TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity. PNAS 2020 Jul 13:201920122. doi: 10.1073/pnas.1920122117. Online ahead of print. PMID: 32661165.
- Scotto Rosato, A., Montefusco, S., Soldati, C., Di Paola, S., Capuozzo, A., Monfregola, J. Polishchuk, E., Amabile, A., Grimm, C., Lombardo, A., De Matteis, M.A., Ballabio, A., Medina, D.L. TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway. Nature Commun 10:5630, 2019.
- Goodridge, J., Jacobs, B., Saetersmoen, M., Clement, D., Clancy, T., Skarpen, E., Brech, A., Landskron, J., Grimm, C., Pfefferle, A., Meza-Zepeda, L., Lorenz, S., Thune Wiiger, M., Louch, W.E., Heggernes Ask, F., Liu. L.L., Yi Sheng Oei, V., Kjällquist, U., Linnarsson, S., Patel, S., Taskén, K., Stenmark, H., Malmberg, K.-J. TRPML1-mediated modulation of dense-core granules determines functional potential in NK cells. Nature Commun 2019 Jan 31;10(1):514. doi: 10.1038/s41467-019-08384-x.
- Villella, V.R., Venerando, A., Cozza, G., Esposito, S., Ferrari, E., Monzani, R., Spinella, M.C., Oikonomou, V., Renga, G., Tosco, A., Rossin, F., Guido, S., Bear, C.E., Silano, M., Garaci, E., Chao, Y.-K., Grimm, C., Luciani, A., Romani, L., Piacentini, M., Raia, V., Kroemer, G. & Maiuri, L. A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J 2019 Jan 15;38(2). pii: e100101. doi: 10.15252/embj.2018100101. Epub 2018 Nov 29.
- Chao Y-K, Schludi V, Chen C-C, Butz E, Nguyen, P., Müller, M., Krüger J, Kammerbauer C, Vollmar, A., Berking C, Biel M, Wahl-Schott C, Grimm C#: TPC2 polymorphisms associated with a human hair pigmentation phenotype result in gain of channel function by independent mechanisms. PNAS 114:E8595-E8602, 2017.
- Chen C-C, Chunlei C, Fenske S, Butz E, Chao Y-K, Biel M, Ren D, Wahl-Schott C, Grimm C#: Patch clamp technique to characterize ion channels in individual intact endolysosomes. Nature Protoc 12:1639-1658, 2017.
- Ruas M, Davis LC, Chen C-C, Morgan AJ, Chuang K-T, Walseth TF, Grimm C, Garnham C, Powell T, Biel M, Wahl-Schott C, Parrington J, Galione A: Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J 34:1743-1758, 2015.
- Sakurai Y, Kolokoltsov AA, Chen C-C, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA: Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment, Science 347:995-998, 2015.
- Chen C-C, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C#: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature Commun 5:4681, 2014.
- Grimm C, Holdt LM, Chen C-C, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C: High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nature Commun 5:4699, 2014.
- Aneiros E, Cao L, Papakosta M, Stevens EB, Phillips SC, Grimm C#: Biophysical and molecular basis of TRPV1 proton gating. EMBO J 30:994-1002, 2011.
- Grimm C, Cuajungco MP, van Aken AFJ, Schnee M, Jörs S, Kros CJ, Ricci AJ, Heller S: A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. PNAS 104:19583-19588, 2007.
* authors contributed equally; # corresponding or shared corresponding author
Full list of publications
Link to Publons:
https://publons.com/researcher/3943443/christian-grimm/