RESEARCH

 

 

 

Lysosomal dysfunction can result in lysosomal storage disorders (LSDs) such as mucolipidoses but it is also implicated in the development of more common neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, metabolic diseases, retinal diseases and pigmentation disorders, trace metal deficiencies such as iron deficiency, and also cancer and immune diseases. Highly critical for the proper function of lysosomes, endosomes, and lysosome-related organelles (LROs) is the tight regulation of various fusion and fission processes and the regulation of proton and other cation concentrations within the endolysosomal system (ES). TRPML cation channels (TRPML1, 2 and 3) and Two-pore channels (TPC1, TPC2) have recently emerged as important regulators of such processes within the ES and appear to be essential for a proper communication between the various endolysosomal vesicles. We use endolysosomal patch-clamp techniques, molecular and cell biology techniques as well as knockout mouse models to study the physiological roles and activation mechanisms of these ion channels in more detail with the ultimate aim to explore the potential of these ion channels as drug targets for a range of different diseases.

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Press links:

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German:

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https://www.lmu.de/de/newsroom/newsuebersicht/news/lysosomale-speicherkrankheiten-ionenkanal-als-moegliche-zielstruktur-fuer-therapien.html

https://www.cup.uni-muenchen.de/de/aktuelles/archiv/2022/copd-ionenkanal-reguliert-krankheitsfoerderndes-molekuel/
https://www.lmu.de/de/newsroom/newsuebersicht/news/copd-ionenkanal-reguliert-krankheitsfoerderndes-molekuel.html

https://www.uni-muenchen.de/forschung/news/2020/grimm_mechanosensitivitaet.html

https://www.cup.uni-muenchen.de/de/aktuelles/archiv/2017/pharmakologie-im-strom-der-blaeschen/?lang=de

https://www.cup.uni-muenchen.de/de/aktuelles/archiv/2016/kinderdemenz-defekten-ionenkanaelen-auf-der-spur/?lang=de

https://www.med.uni-muenchen.de/aktuell/2019/grimm_ncl/index.html

https://www.cup.uni-muenchen.de/de/aktuelles/archiv/2014/defekter-ionenkanal-beguenstigt-fettleber/?lang=de

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English:

https://www.lmu.de/en/newsroom/news-overview/news/copd-ion-channel-regulates-molecule-that-contributes-to-disease.html

https://www.cup.uni-muenchen.de/en/events-and-news/archive/2022/copd-ion-channel-regulates-molecule-that-contributes-to-disease/?lang=default

https://www.cup.uni-muenchen.de/en/events-and-news/archive/2017/pharmacology-probing-the-pores-in-membrane-vesicles/?lang=default

https://www.cup.uni-muenchen.de/en/events-and-news/archive/2014/metabolic-disease-unlocking-a-jammed-ion-channel/?lang=default

https://www.cup.uni-muenchen.de/en/events-and-news/archive/2016/childhood-dementia-defining-an-enigmatic-but-vital-function/?lang=default

https://www.lmu.de/en/newsroom/news-overview/news/unconventional-ion-channel-identified.html

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